Preston boss Phil Brown will be without rookie defender Daniel Devine for the home clash with Notts County.
Devine has been ruled out of action for up to four weeks after sustaining a broken jaw following an incident in Preston city centre last weekend.
The 18-year-old, who started in North End's last four games, is currently back home with his family in Northern Ireland as he recovers from the injury sustained just hours after the 1-0 home win over Exeter.
Influential skipper Iain Hume missed the Exeter game with a thigh injury, while left-back Steven Smith was also absent due to a calf complaint.
Hume and Smith should be fit to face the Magpies and rookie defender Conor McLaughlin is also edging closer to full fitness.
The 20-year-old came on as a late substitute against Exeter for his first appearance since suffering a fracture and dislocation of his ankle in February.
Notts County have problems in central midfield.
Captain Neal Bishop will be suspended at Deepdale after he was sent off for two bookable offences during the defeat at Sheffield Wednesday last weekend.
He joins Ricky Ravenhill, who is still suffering from concussion following the victory over Tranmere 10 days ago, on the sidelines.
However, manager Martin Allen has moved to plug the void by signing the experienced Gavin Mahon on a pay-as-you play deal until January. He could make his debut on Saturday.
Allen is also hoping to boost his squad further with the addition of a striker before the game.
Striker Karl Hawley is set to return to Preston for the first time since leaving Deepdale to join Notts two years ago.
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