Saturday heralds a new era for West Ham as they begin life without three-time Hammer of the Year Scott Parker, following the England midfielder's deadline day move to Tottenham.
However, the east London club take on Portsmouth at Upton Park with a number of new faces in their ranks, having indulged in some late transfer activity of their own.
The Hammers signed Henri Lansbury, David Bentley and Guy Demel on the final day of the transfer window, with Sam Baldock having joined from MK Dons the previous week.
In fact, Sam Allardyce brought in no fewer than 12 new recruits over the summer, with the latest additions in line to make their debuts this weekend.
Allardyce's No.2, Neil McDonald has certainly been enthused by the new crop, with Baldock and Demel being reserved particular praise from the popular coach.
"Sam [Baldock] has trained with us for a few days and has looked very sharp in front of goal. He has fantastic movement, is quick over the ground and is a goal-scorer," McDonald to whufc.com.
"I think that's evident from what he's done with MK Dons over the last couple of seasons.
"He has scored goals for fun so if he can get into the team and we have give him the service, that will be fantastic for us."
He added: "Guy [Demel] has come in with a good reputation. He can play all over the place - at right-back and centre-half.
"He looks fit and well and has played at a high level in Germany and is obviously an Ivory Coast international.
"He's a fantastic signing and it gives plenty of scope for the manager to change things around if he needs to."