Plymouth boss Peter Reid will be able to call on Conor Hourihane and Warren Feeney for the League Two clash with Port Vale.
The pair missed last weekend's defeat to Burton while on international duty but will be available against the Valiants.
Striker Feeney was involved with the Northern Ireland squad which lost European Championship qualifiers to Estonia and Serbia over the weekend.
On-loan midfielder Hourihane was part of the Northern Ireland Under 21s set-up for their defeats to Denmark and Serbia in the same period.
Loan signings Simon King and Jamie Griffiths are expected to feature in some capacity for the Pilgrims, who have taken just one point from their opening six league outings.
Romain Larrieu may return in goal after recovering from a neck problem. The stopper was replaced by Jake Cole in the 2-1 loss to Burton last week, despite claiming he was fully fit.
Port Vale hope to have Sean Rigg and Doug Loft available.
Striker Rigg and midfielder Loft are the club's top scorers with four goals apiece but suffered hamstring and knee injuries respectively during the 3-2 home defeat by Southend 10 days ago.
Both missed out as Vale lost by the same scoreline at AFC Wimbledon last weekend but the duo are on course to bolster Micky Adams' side and are likely to go straight back into the starting XI if fit.
Marc Richards made his long-awaited comeback from an ankle injury as a second-half substitute against the Dons and the striker continued to step up his recovery with a goal-scoring outing for the reserves in midweek.
Midfielder Ryan Burge is struggling to overcome a thigh injury while defender Lee Collins will miss out with a hernia problem.
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