The Champions League group stages kick off tonight, with Chelsea welcoming Bayer Leverkusen and Arsenal facing Borussia Dortmund.
Chelsea coach Andre Villas-Boas faces a choice between the misfiring Fernando Torres and Daniel Sturridge, who impressed at the weekend.
New signing Raul Merieles is also in line to start after a good display at Sunderland, while John Obi-Mikel could return alongside him.
Arsene Wenger starts his own two-match touchline ban as his side face a difficult match against German champions Dortmund away from home.
Wenger will be relying on his new signings including Mikel Arteta and Gervinho after Aaron Ramsey and Tomas Rosicky were both ruled out.
Neil Warnock’s new-look QPR side drew 0-0 with Newcastle last night, with Shaun Wright-Phillips and Joey Barton making their debuts.
The former Newcastle midfielder was appointed captain ahead of facing his old club. Newcastle now sit in 4th on the table, with QPR in 11th.
Arsenal are to return with an improved bid for Bolton defender Gary Cahill as Arsene Wenger looks to continue revamping his squad.
Harry Redknapp is ready to launch a move for Christopher Samba, with injuries once again decimating Tottenham’s defence this season.
And finally, rumours in the Italian press suggest Chelsea could be tempted into swapping Fernando Torres for AC Milan’s Alexandra Pato.