The two Barclays Premier League giants go head-to-head on Sunday, with the Blues heading into the clash on the back of a 2-0 win over their Bundesliga opponents, with David Luiz breaking the deadlock and Juan Mata sealing the win at Stamford Bridge.
It was a night of positives for the Blues after resting skipper John Terry and vice-captain Frank Lampard for the tie, with Fernando Torres a particular plus point for Andre Villas-Boas. The Spanish striker, whilst failing to grab an elusive goal, added two assists to his name.
"The problem is solved. The investigation is over. We had a chat and the situation is solved," said the former Porto boss in relation to an interview given by the player whilst on international duty, suggesting some of the senior members of the squad at Chelsea were 'old' and 'slow'.
"You saw the player involved [last night] and he put in a good collective performance, like the team had. Hopefully these things won't arise in the group again. If they do, it'll be the manager who has to resolve it."
Despite the impressive display from Torres, the former Atletico Madrid star is not guaranteed a place in the starting line-up when the Blues travel to Old Trafford.
Whilst Didier Drogba is likely to miss the match having failed to recover from an ugly looking injury picked up against Norwich City, a handful of other players are in contention to start in attacking positions, namely Daniel Sturridge and Nicolas Anelka, who made a positive impact off the bench against Leverkusen.
Villas-Boas is under no illusions with regards to the challenge awaiting his side in Manchester, with the Red Devils perfect so far this season, claiming four wins in four games.
“We have another couple of days to train, and he [Torres] will compete with the other four [strikers] for that position. We have to take the best decision possible," said the manager post-match.
"We face United perhaps in their most tremendous moment of motivation and flair and style. Motivation will be the key factor in the game, and the capacity of people to transcend themselves and take the game through and come back from Old Trafford with a win," said the manager post-match.
"A team that has made its impact at the beginning of the Premier League is different from last year, but I think it provokes in us a good challenge."