Oxford will be without captain Jake Wright for their clash with Accrington.
The 25-year-old defender was dismissed after picking up two yellow cards against Barnet last weekend, incurring a one-match ban.
The Us will also be without long-term injury victims Tony Capaldi, Tom Craddock and Anthony Tonkin.
Veteran defender Capaldi still needs at least three more weeks of recovery time as he recuperates from a back injury, while full-back Tonkin will be sidelined for another month with a hamstring problem.
Striker Craddock continues to battle a knee problem which has kept the former Luton forward out of action all season.
Hitman Jonathan Franks returned to parent club Middlesbrough last week after discovering his dislocated shoulder is likely to keep him out until Christmas.
Accrington boss John Coleman will be without Nat Taylor and Louis Moult for the match.
Taylor is in the middle of the 35-day ban he received after being sent off for Accrington and Rossendale College last season - before the midfielder had penned professional terms.
Meanwhile, forward Moult has returned to parent club Stoke after his month-long loan deal with Stanley expired earlier this week.
Coleman has no new injury worries but he may opt to make tactical changes as his Accrington side bid to end a run of three games without a win.
Charlie Bennett will be pushing for a starting berth after the midfielder missed out in the 2-0 defeat to Crewe last week following his return from a three-match ban.
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