First-half goals from Rafael van der Vaart and Gareth Bale sealed a 2-1 win for Tottenham but they were forced to cling on in the face of a late assault by 10-man Wigan.
Van der Vaart swept home a third-minute opener after an error by Maynor Figueroa, then Bale headed home a corner from Luka Modric.
Spurs should have been out of sight at half-time but Wigan struck back in the 49th minute through Mohamed Diame before Steve Gohouri's 63rd-minute dismissal hit their hopes of a comeback.
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