Injured Manchester United duo Wayne Rooney and Javier Hernandez will be unavailable for Tuesday night's Champions League encounter with Basel.
United take on the Swiss champions at Old Trafford in Group C of Europe's premier club competition, and will be looking to notch their first win on the continent this season.
Sir Alex Ferguson's side were held at Benfica in their opening fixture and will now be without their two most potent strikers as they target three points against Basel.
Rooney missed Saturday's draw with Stoke due to a hamstring injury and did not train fully on Monday, while Hernandez suffered a dead leg at the Britannia Stadium.
Ferguson, however, will have in-form Michael Owen, last season's top scorer Dimitar Berbatov and fit again Danny Welbeck to chose from, and had always intended to rotate his squad for Basel.
But the United boss is not expecting an easy ride against Thorsten Fink's well organised outfit, who currently sit top of the group after an opening victory against Oţelul Galaţi.
"I think we got a positive result against Benfica," said Ferguson. "Hopefully, we can strengthen our position. Basel are a decent side though.
"Thorsten Fink was a substitute in the final for Bayern Munich in 1999 when he came on for Lothar Matthaus. I spoke to him at the UEFA conference and he's done a good job.
"If you get to 10 points, you know you're into the next stage but we'd like to win the group anyway. If we win our next three games, we can utilise the squad. It would definitely help and we've done that over the years.
"It's sometimes backfired - I played a fresh team over in Fenerbahce and they beat us 3-0. Although I want to make changes, I don't want an embarrassment. So changes have got to be made with a mind of still winning the game."