Another huge weekend of Barclays Premier League action kicks off on Saturday when Everton and Liverpool clash for the Merseyside derby.
Steven Gerrard is set to return to the starting line up, while manager Kenny Dalglish is expected to persist with Andy Carroll up front.
Sir Alex Ferguson's men will be looking to get back to winning ways after disappointing draws against Stoke and Basel this week.
The Red Devils will likely miss Wayne Rooney, with Danny Welbeck, Javier Hernandez and Dimitar Berbatov competing for a starting place.
Roberto Mancini's men will be firm favourites as they aim to put the Carlos Tevez saga behind them with three points at Blackburn.
Edin Dzeko has apologised for his own behaviour during the incident at Bayern Munich, paving the way for a start alongside Sergio Aguero.
Elsewhere, Sunderland welcome West Brom, with under pressure Black Cats manager Steve Bruce especially desperate for the three points.
Villa sit in a respectable 8th place in the table, yet with just one win to their name, Alex McLeish will demand a win against Roberto Martinez's men.
Finally on Saturday, Wolves take on Newcastle, who have defied critics with an impressive start to the season - remaining unbeaten.
Sunday sees the biggest North London derby for years when Spurs clash with Arsenal at White Hart Lane, with both sides on the up after poor starts.
Alex Oxlade-Chamberlain could be a key player at White Hart Lane, if as expected he is given the nod to start for Arsene Wenger's side.
Emmanuel Adebayor will start against his former club, as the home side look to maintain their two year unbeaten North London derby record.
Andre Villas-Boas's side travel to the Bolton hoping to inflict more misery on Owen Coyle's side, who sit rock bottom of the table.
Fernando Torres is suspended after being sent off last week, with Didier Drogba and former Bolton loanee Daniel Sturridge expected to start.
Also on Sunday, Fulham and QPR meet for the West London Derby, with the home side still looking for their first win of the season.
Swansea and Stoke bring the weekend to a close. with Tony Pulis hoping to avoid a Europa League hangover after Thursday's European exertions.
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