Whilst geographically both clubs have bigger 'derby' matches, few games in the world can compare to the fiery nature of Liverpool against Manchester United, particularly at Anfield.
The two clubs have enjoyed long periods of dominance in English football, notably in the 80s for the Reds, followed by the 90s and 00's for the Red Devils.
It's rivalry, in recent times at least, stems back to quotes from Sir Alex Ferguson on his arrival at Old Trafford in 1986.
25 years later, United have 'knocked Liverpool off their perch' and overtaken the Merseysiders' 18 league titles, claiming their own 19th last season.
However, their recent form at Anfield has been a concern to Ferguson, and after a six-year period of success at the ground (P:6, W:5, D:1, L:O), Liverpool have been victorious in the last three matches between the teams.
"We have been poor there of late. On a couple of occasions we have been out-fought by them, which is disappointing," said Fergie ahead of their clash on October 15th.
"The atmosphere plays a part. Every time we go there it is as if it's the biggest game of the century."
Dirk Kuyt's hat-trick secured victory for the hosts last time out, and United's youngsters can expect an intimidating atmosphere against Kenny Dalglish's resurgent Reds.