Plymouth's caretaker player-manager Carl Fletcher serves the last match of a three-game suspension for the visit of Accrington.
Fletcher was banned after he was sent off at Southend on September 17. Otherwise the Pilgrims boss has a full-strength squad to choose from for the clash - which represents the 125th anniversary of Argyle's first-ever match.
After winning their first game of the campaign in their previous home outing, Argyle could haul themselves off the bottom of League Two with a victory, should other results go their way.
And the match may be the club's last in administration, with businessman James Brent close to completing a takeover at Home Park.
Plymouth are hopeful Gillingham do not recall defender Simon King from his loan spell. The Gills have five defenders ruled out or doubtful for their clash with Port Vale.
But Gillingham manager Andy Hessenthaler is reluctant to bring King back, telling BBC Radio Kent: "I don't think he'll be back for this weekend. If we do pick up any more, it may be an option for us."
Accrington will be without on-loan defender Tom Bender.
Stanley's Johnstone's Paint Trophy tie with Tranmere was abandoned on Tuesday after Bender suffered severe concussion following a collision with team-mate Ian Dunbavin.
The 18-year-old needed extensive treatment but has since been released from hospital and returned home although Stanley are putting no timetable on when he will be back in action.
Sean Hessey is likely to slot in at the heart of Accrington's defence in place of Bender.
Left-back Dean Winnard is another doubt for manager John Coleman. Winnard missed the game with Rovers after sustaining an ankle injury in the 3-2 victory over Aldershot on Saturday.
Peter Murphy will start on the left of Coleman's back four should Winnard not make the game.
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