Czech Republic v Spain
Generali Arena - Praha
Euro 2012 Qualifying Group I
Friday 7 October, 19:45 kick-off
Czech Republic will welcome back the services of Chelsea goalkeeper Petr Cech, who missed the last round of international matches with a knee ligament injury.
Andres Iniesta has not been risked as the Barcelona midfielder continues his recovery from a hamstring team, while club teammate Cesc Fabregas has also been forced to withdraw from the Spanish squad with a hamstring problem.
Vicente Del Bosque has indicated he will make changes to his starting line-up with the reigning World and European champions already qualified for the Euro 2012 finals.
That means that Carles Puyol and Gerard Pique will likely have to settle for a place on the bench as the pair also build up their fitness following injury.
Villa threat could prove deadly
Spain will be looking to maintain their 100 per cent record in Euro 2012 qualification Group I, when they travel to Prague to face 2nd placed Czech Republic on Friday evening.
A David Villa brace after going a goal down ensured victory for Vicente Del Bosque's side when the two nations met in the reverse fixture, and the in-form striker will be looking to maintain his goalscoring form, having netted six goals in six group appearances for Spain.
The absence of Iniesta and Fabregas means that the centre of midfield could feature promising Chelsea star Juan Mata, alongside mainstay Xavi.
Czech Republic have plenty more to play for, as they look to cement their play-off place, and if Scotland fail to win against Liechtenstein, then coach Michal Bilek's side can achieve that with victory tonight.
But Spain have tremendous strength in depth in their squad, so even with the inevitable player changes they will provide a tough test for Czech Republic, who will look to Arsenal midfielder Tomas Rosicky as the man to orchestrate the attacking play.