Call it what you like, the Lancashire derby, the North-West derby or the Sky Sports derby, Liverpool against Manchester United is a meeting between the two most successful sides in English league football.
United usurped Liverpool as the dominate force in the league two seasons ago, having collected their record 19th league title. But, this weekend provides the Reds with another opportunity to set the record straight and, if the Anfield club have no ambitions of winning the title themselves, then they can at least chase bragging rights against the Red Devils.
To help look ahead to the weekend's clash, GMF have profiled the best five matches in the Barclays Premier League era between the two sides at Anfield. Both sides have eight wins to their name at Liverpool's home, with four draws from the 20 Premier League meetings, so just like their head-to-head record, expect a tight affair on Sunday.
5. Liverpool 3–1 Manchester United
4 November 2001
Despite United having won three successive league titles, it was Liverpool who were enduring a period of dominance in the head-to-head battles.
Michael Owen first capitalised on a Wes Brown error, before John Arne Riise struck a ferocious free-kick past Fabian Barthez.
David Beckham did pull a goal back, but after Barthez flapped at a long throw, Owen's predatory instinct came to the fore once more to secure The Reds fourth successive win over United.
4. Liverpool 1–3 Manchester United
6 December 1997
Build very much a Premier League title decider, it was the reigning champions who took home the bragging rights, and went on to secure what would be a fourth league crown in five seasons.
In a game of four headers, Gary Pallister leapt first to give United an early lead, before John Barnes caught Peter Schmeichel unawares as he stooped to equalise.
Pallister's second before half time restored United's lead, before Andy Cole capitalised on an error from David James as the title headed to Old Trafford.
3. Liverpool 2–2 Manchester United
5 May 1999
United were vying with Arsenal for the title, but Liverpool were keen to disrupt their run to the first part of an elusive treble.
Dwight Yorke opened the scoring with a flying header from Beckham's cross, before Dennis Irwin's penalty gave United the initiative.
However, Jamie Redknapp's spot kick and Irwin's sending off set-up a grand stand finale, which saw former United player Paul Ince equaliser late on.
2. Liverpool 2–3 Manchester United
11 September 1999
United hit the front early on through Jamie Carragher's own goal before Cole headed in Beckham's free-kick.
Then Massimo Taibi entered the stage, flapping at a set-piece to allow Sami Hyypia to head home, before Carragher put through his own net before half-time
Taibi saved brilliantly from Vladimir Smicer and then Robbie Fowler before Patrick Berger slotted in what turned out to be a mere consolation.
1. Liverpool 3–3 Manchester United
4 January 1994
As a good a clash between these two sides as the Premier League has ever produced.
United stormed into a three-goal lead through Steve Bruce, Ryan Giggs' delightful chip and Irwin's free-kick before Liverpool responded in similarly devastating fashion
Nigel Clough scored twice for the hosts before the break, before Neil Ruddock's second half header rescued a point.