Liverpool: Reina, Kelly, Enrique, Carragher, Skrtel, Lucas, Adam, Gerrard, Downing, Kuyt, Suarez
Substitutes: Doni, Agger, Robinson, Henderson, Spearing, Carroll, Bellamy
Manchester United: De Gea, Evra, Jones, Ferdinand, Evans, Giggs, Smalling, Park, Young, Welbeck, Fletcher.
Substitutes: Lindegaard, Anderson, Carrick, Nani, Valencia, Rooney, Hernandez
Liverpool captain Steven Gerrard is set to make his first start in over seven months after recovering from a recurring groin problem.
Kenny Dalglish has a fully-fit squad to chose from, after defensive trio Glen Johnson, Martin Kelly and Daniel Agger have all recovered from their respective injuries.
Meanwhile, Manchester United captain Nemanja Vidic will be left to decide himself if he is ready to return to action after featuring for Serbia in the midweek international following his recovery from a calf strain.
Chris Smalling faces a late fitness test, but Tom Cleverley and Rafael Da Silva will miss the trip to Anfield.
Downing aims to keep momentum
Stewart Downing has urged his Liverpool teammates to pick up from where they left off before the international break, and utilise the club's impressive home record when Manchester United visit Anfield this weekend.
Back-to-back victories against Wolves and Everton had started to build a good momentum for Kenny Dalglish's side, and Downing wants to keep that going by extending the Reds winning run, having emerged victorious from all of the last three Merseyside meetings with United.
"It's a tough game but we'll look forward to it and if we keep playing the way we are then we've got a chance of beating anyone," said Downing.
Liverpool's last victory was almost a fortnight ago, and like the England international, most players have been away with their national teams, so the break may have done the side more harm than good.
"If we beat Manchester United we'll say the break did us good," Downing continued. "If we don't people will point the finger and say the break killed us a bit."
Meanwhile, fellow midfielder Charlie Adam has identified the battle in the middle of the park as being the key to victory over the reigning Barclays Premier League champions on Saturday, and remains confident of securing the win.
"The key normally in these games is the midfield," he told Liverpoolfc.tv. "If you can get a grip of the game in midfield then I think you can win the match.
"You also need somebody up front who can score you goals and we have certainly got that. We are confident going into the game and hopefully come Saturday we can get the three points."