Manchester United host Manchester City on Sunday in the biggest derby between the two for a number of years.
City are currently top of the Barclays Premier League and can extend the gap over their neighbours to five points with victory on Sunday at Old Trafford.
Elsewhere, Chelsea can close the gap on the Manchester duo with a win against newly promoted Queens Park Rangers, who have enjoyed inconsistent form on their return to the top-flight.
Arsenal are looking to continue their progress with another three points on Sunday, although the Gunners will face a stern test as Stoke City travel to the Emirates Stadium.
Tottenham also play on Sunday, with Blackburn the hosts for Harry Redknapp's side, who beat Rubin Kazan in the Europa League on Thursday.
Liverpool are the most high-profile side to feature on Sunday, and welcome Paul Lambert's Norwich City to Anfield for the first time since 2004.
Meanwhile, Fulham face Everton, Aston Villa and West Brom contest the west Midlands derby, Wolves meet Swansea, Sunderland travel to Bolton and Newcastle host Wigan.