Manchester United will be looking to bounce back from last weekend's humiliating loss to Manchester City with three points against Everton.
The Barclays Premier League champions travel to Goodison Park for Saturday's early kick off with Nemanja Vidic and Tom Cleverley available for selection.
Also early on Saturday, Chelsea take on Arsenal at Stamford Bridge in what will surely be an action-packed London derby.
John Terry will play for Chelsea, despite his off-field issues, and will have to be at his best to extinguish the threat posed by in-form Robin van Persie.
Manchester City can extend their advantage at the top of the table with victory over Wolves at the Etihad Stadium, having beaten Mick McCarthy's side 5-2 in the Carling Cup on Wednesday.
Liverpool are also in action on Saturday, and face former boss Roy Hodgson for the second time since the West Brom boss left Anfield.
Elsewhere on tomorrow, Norwich host bottom placed Blackburn, Sunderland face Aston Villa at the Stadium of Light, Bolton travel to Swansea and Wigan meet Fulham.
On Sunday, Tottenham welcome Queens Park Rangers to White Hart Lane, while Stoke and Newcastle play at the Britannia Stadium on Monday.
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