Arsenal v West Brom
Resurgent Arsenal will look to build upon last week's momentous victory at Chelsea with another 3 points when West Bromich Albion visit the Emirates Stadium.
With Robin van Persie is in the form of his life and Thomas Vermaelen's return strengthening a fragile defence, Arsene Wenger is confident of a win.
Blackburn v Chelsea
Chelsea meanwhile will be looking to bounce back after a difficult fortnight that have seem them stumble in both at home and in Europe.
Ahead of the game, Andre Villas-Boas spoke of a need for Chelsea to improve their solidity at the back, while calling for his side to finish their chances.
Liverpool v Swansea
Kenny Dalglish believes Liverpool are better equipped this season to deal with recent injuries to both Steven Gerrard and Jamie Carragher.
Recent signings such as Luis Suarez, Andy Carroll and Charlie Adam will be relied upon to maintain the Reds impressive form, that has seen them unbeaten in 5 games.
Manchester United v Sunderland
Sir Alex Ferguson will be hoping to celebrate a phenomenal 25 years in charge at Old Trafford with victory over Sunderland on Saturday.
With Anderson and Tom Cleverley, among others, on the injury list, Wayne Rooney may start in midfield United look to keep pace with Manchester City.
QPR v Man City
Roberto Mancini's side are in fantastic form and eager to strengthen their position at the top of the table as they visit Loftus Road on Saturday.
Mario Balotelli has almost certainly earned a starting berth with 7 goals in as many games, while Stefan Savic will replace the suspended Vincent Kompany.
Newcastle v Everton / Aston Villa v Norwich
Elsewhere on Saturday, Newcastle will be aiming to extend their impressive unbeaten start against Everton, while Aston Villa welcome Norwich.
Fulham v Tottenham
On Sunday, Tottenham face Fulham eager to maintain their brilliant form -
having not lost a single game in the Premier League since August.
Scott Parker and Emmanuel Adebayor will once again be instrumental, while Rafael van deer Vaart will be looking for extend his record scoring streak.
Wolves v Wigan
Elsewhere on Sunday, Wolverhampton take on Wigan, with 3 precious points on offer that could already prove very important come the end of the season.
Bolton v Stoke
Finally, Bolton welcome Stoke City with both teams desperate to remedy their inconsistent form with a victory.