Rafael van der Vaart was injured for Holland on Friday on a weekend of mainly positives for Tottenham's European players on international duty.
The Dutch midfielder was, once again, forced off with a hamstring injury as Holland drew 0-0 with Switzerland on Friday night.
Van der Vaart will definitely miss Tuesday's friendly with Germany, and the severity of the 28-year-old's problem is yet to have been revealed.
Meanwhile, Scott Park was named man-of-the-match for his performance in England's victory over World Cup winners Spain at Wembley.
The tenacious midfielder worked tirelessly as the Three Lions secured a somewhat surprising 1-0 victory thanks to a goal from Frank Lampard.
"Scott Parker had an incredible performance," said England boss Fabio Capello.
"He is improving every game. He is an important player.
"He can receive the ball from the back four no problem - a really good player."
Spurs duo Luka Modric and Vedran Corluka also performed to distinction as Croatia seized a huge advantage going into the second leg of their Euro 2012 playoff with Turkey.
Corluka netted the final goal as Slaven Bilic's side won 3-0 in Istanbul to all but book their place in next summer's tournament.