Wigan Athletic v Arsenal; DW Stadium; Barclays Premier League; Saturday 3 December 2011, 15:00
Emmerson Boyce could return to the Wigan squad after missing the last two matches through injury, but Antolin Alcaraz will not be available for the Latics, as he serves the final game of his three-match ban for spitting at Wolves defender Richard Stearman.
Meanwhile, Arsenal travel to the DW Stadium without midfielders Abou Diaby and Tomas Rosicky, who are ruled out with hamstring and thigh injuries respectively.
Long-term absentees Carl Jenkinson and Bacary Sagna are at least three weeks away from a first-team return, and will not feature for Arsene Wenger's side.
Gunners goals aren't just Robin reliant
Robin Van Persie has scored 13 times in the Barclays Premier League alone this season - half of Arsenal's top-flight tally in 2011-12 - but despite the remarkable stat, Arsene Wenger is confident that other players can contribute in his absence.
The Gunners captain sat out of Tuesday evening's Carling Cup defeat at the Emirates Stadium, as Manchester City snatched a 1-0 win over the north Londoners second-string.
"At the moment I can't deny that [we rely on him for goals]," Wenger told Arsenal player. "But I believe that the likes of Gervinho, Aaron Ramsey and Theo Walcott can score goals and I believe they will.
"They can score goals, I am am completely confident of that. And they will score.
"At the moment Robin is always on the end of things. I think he will continue but I also think it will change that the other players will score goals as well."
After a dreadful start to the 2011-12 campaign, Arsenal have succeeded in turning their season around and have been on a fine run of form.
However, the Gunners played out a frustrating 1-1 draw with Fulham last weekend, and Wenger has revealed he is looking for a response from his players.
"In the Premier League we are on a good run and we want to continue that," he added. "It's important that we respond well [to the draw at Fulham].
"A successful season is based on that - how much a team can respond to a disappointment and how quickly you can come back and win a game. That's what is at stake."