Fleetwood Town will kick-off the fight for the FA Cup third round when they face perennial giant killers Yeovil Town.
The Glovers have long been known for producing a shock in the early round of the world oldest cup competition, but will go into Friday night trip to Highbury fearing the worst after The Trawlermen's win over fellow League One side Wycombe Wanderers in round one.
On Saturday, Stourbridge, conquerers of the Football League's bottom club Plymouth Argyle, will host Stevenge Borough, a winner of two promotions in three years.
The pick of the 3pm kick-offs on Saturday see Crawley Town host the lowest ranked side left in the competition in Redbridge, who will be hoping to repeat the Red Devils' heroics during last season's competition.
Steve Evans' side over a side from each division of the Foootball League, in Swindon Town, then of League One, The Championships' Derby County and League Two's Torquay United on their way to facing Manchester United in round five, in a money spinning tie for the non-league big spenders.
After having won promotion from the conference last season, and now second in League Two, Crawley are their to be shot at.
Other none-league sides looking for a money-spinning tie in round three include Chelmsford City, who host Macclesfield Town and Conference leaders Wrexham who visit Brentford.
The competition is guaranteed at least two none-league sides in the third round, as Southern League side Salisbury City take on Grimsby Town and Gateshead host Tamworth.
There are just two all League Two ties with Bradford City taking on newly promoted AFC Wimbledon and Shrewsbury Town playing host to Rotherham United.
League One's top two will feel confident of progressing as Charlton Athletic take on Carlisle United, with Sheffield Wednesday hosting Aldershot Town.
Elsewhere, Sheffield United meet Torquay United, Colchester United take on Swindon Town, Leyton Orient play Gillingham, Barnet meet Milton Keynes Dons and Oldham Athletic travel to Southend United.
On Sunday, two more non-league sides take the plunge hoping to swine rather than sink.
AFC Totton, 8-1 winners in round one, host Bristol Rovers, while Sutton United take on Notts County.