Newcastle United v Chelsea
Chelsea kick off this weekend's Barclays Premier League action, desperate for a positive result after 4 defeats in the last 6 games.
Oriol Romeu is expected to start, but under pressure Chelsea manager Andre Villas-Boas is likely to leave misfiring striker Fernando Torres out.
Aston Villa v Manchester United
Sir Alex Ferguson's side will be looking to bounce back from their shock exit from the Carling Cup earlier this week with victory at Villa Park.
With the Red Devils dropping points in recent league fixtures, a win is essential if they are to keep up the pressure on Manchester City.
Manchester City v Norwich City
The league leaders welcome Norwich, aiming to continue their unbeaten run, with Mario Balotelli set to return to partner Sergio Aguero in attack.
Wigan Athletic v Arsenal
Arsene Wenger's side visit the DW Stadium on Saturday, with Thomas Vermaelen and Robin van Persie set to start having been rested in midweek.
Tottenham Hotspur v Bolton Wanderers
Rafael van der Vaart will return to Tottenham squad after overcoming injury, but could start on bench will Jermain Defoe partnering Emmanuel Adebayor.
Blackburn Rovers v Swansea City | QPR v West Bromich Albion
Elsewhere on Saturday, struggling Blackburn face Swansea City, while QPR welcome West Brom, looking for their second home win this season.
Eveton v Stoke City
On Sunday, Everton take on Stoke City, with David Moyes side aiming for the third consecutive win after a disappointing start to their campaign.
Wolves v Sunderland
Finally, Wolves face Sunderland, in a game new Sunderland manager Martin O'Neill - who officially starts Monday - will be watching with interest.