Arsenal v Everton
Arsenal kick off this weekend's Premier League action, as they welcome an Everton side to the Emirates Stadium who have not beat them in 15 years.
Arsene Wenger will be forced to reshuffle his defence with Andre Santos injured, with Johan Djourou expected to fill in the Gunners look to maintain their great run.
Liverpool v QPR
Liverpool take on QPR at Anfield, with Kenny Dalglish's desperate for a win after dropping points in their last three Barclays Premier League matches.
Dalglish will be without the suspended Jay Spearing, as well as Lucas Leiva and Steven Gerrard, meaning Jordan Henderson will likely start in centre midfield.
Manchester United v Wolves
Sir Alex Ferguson will be keen for Manchester United to bounce back from their shock UEFA Champions League exit with three points at Old Trafford.
With Nemanja Vidic's season over after a knee injury, Phil Jones will revert to centre back, while Michael Carrick returns to bolster United's midfield options.
Bolton v Aston Villa
Elsewhere, Bolton face Aston Villa at the Reebok Stadium, with both sides going in to the game at the wrong end of the table following poor results.
Norwich v Newcastle
Alan Pardew's side travel to Carrow Road hoping to rediscover their early season form after losing twice, to Chelsea and City, in the last three games.
Swansea v Fulham | West Brom v Wigan
Also on Saturday, Swansea face Fulham, having won just once in their last
seven games, while West Brom play Wigan with both sides struggling for goals.
Sunderland v Blackburn
On Sunday, Martin O'Neill will be aiming for a perfect start to life as manager of Sunderland with three points in his first match against Blackburn.
Stoke v Tottenham
Finally on Sunday, Tottenham face a daunting trip to Stoke City, but will be full of confidence after winning 10 of their last 11 league matches.
Jermain Defoe and Gareth Bale face late fitness tests, while Ledley King is also a doubt. Rafael van deer Vaart is likely to return to the starting line-up.