Manchester City v Manchester United
The FA Cup 3rd Round kicks off this weekend, with United and rivals City set to clash on Sunday in the pick of this weekend's fixtures.
Roberto Mancini has expressed his concerns about the depth of his squad with Yaya and Kolo Toure both off to the African Nations Cup.
Key players including Mario Balotelli and Samir Nasri are unlikely to be fit, with Sergio Aguero certain to lead the line for the league leaders.
Injuries are also mounting at Old Trafford, meaning Wayne Rooney could play in a deep lying role in order to strengthen the Red Devils midfield.
Sir Alex Ferguson will be desperate for his side to bounce back from recent defeats and avenge last years humiliating 6-1 defeat to their bitter rivals.
Liverpool v Oldham
Liverpool manager Kenny Dalglish looks set to make changes as his side welcome League One club Oldham to Anfield this evening.
Steven Gerrard will likely feature as he looks to build up his fitness, while Jamie Carragher and Sebastian Coates could partner in defence.
Tottenham v Cheltenham
On Saturday, Harry Redknapp is expected to rest a number of key players as Tottenham face Cheltenham at home - where they are unbeaten in 8.
Danny Rose, Steven Pienaar and Roman Pavlyuchenko are all likely to begiven a chance to impress as the Spurs manager rotates his squad.
Chelsea v Portsmouth
On Sunday, Chelsea meet Portsmouth at Stamford Bridge - their first meeting since the Blues FA Cup Final triumph over Pompey in 2010.
Didier Drogba has already departed for the African Cup of Nations, while John Obi Mikel and Daniel Sturridge are also doubts.
Arsenal v Leeds United
Arsenal manager Arsene Wenger has confirmed he will rest in form Robin van Persie when his side take on Leeds United on Monday.
Arsenal legend Thierry Henry could make his second debut on the night, having returned to the club on a two month loan deal.