Tottenham Hotspur v Everton
White Hart Lane; Barclays Premier League; Wednesday, 11th January, 2011; 1945 KO.
Scott Parker is a major doubt for the hosts with a knee injury, whilst centre back Ledley King is also out of contention after suffering a hamstring problem in training.
William Gallas and Sandro are both unavailable with calf strains, although Michael Dawson returned over the weekend and is set to partner Younes Kaboul at the back.
Seamus Coleman joins the list of injury concerns for the Toffees, leaving the FA Cup third round win over Tamworth on Saturday with a thigh injury.
Tim Cahill, Jack Rodwell, Phil Jagielka, Leon Osman, Ross Barkley and Tony Hibbert are also expected to miss out at White Hart Lane.
Redknapp predicts sticky Toffees challenge
The Merseyside outfit travel south with a host of injury concerns and a number of first team players out of action, with David Moyes expected to shuffle his pack ahead of the rearranged Barclays Premier League fixture.
Redknapp isn't expecting an easy ride in north London though, and is well aware that the Toffees are always tricky opposition when the two sides meet.
"You'll never get an easy game against Everton. David Moyes does a great job there year in, year out," he told the official Spurs website.
"It's a difficult game, they always put a shift in and they also have dangerous players. I'm sure it will be a tight game, just like it was against Sunderland and West Brom. We took a long time to break them down and I wouldn't expect this to be any different."
Despite their problems, Everton travel to the capital hoping to cause an upset and move into the top half of the table - a draw would take them ninth.
And Sylvain Distin believes the key could be to stifle Tottenham's wingers, with the Frenchman hopeful club captain Phil Neville can keep Gareth Bale at bay like last year.
"I don't understand how he did it because he's so slow! It's just mad. I still don't get it," Distin joked in reference to Neville's efforts against the Welshman on their last league visit to the Lane.
"He did a great job and we're going to have to do it again. And maybe they've got more individual quality throughout the team now, so it's not only stopping Gareth Bale, it's the other players as well."