Manchester United v Bolton
After shock back to back defeats at the hands of Blackburn and Newcastle Sir Alex Ferguson will demand his side take all three points on Saturday.
Paul Scholes could start after his sensational return to Old Trafford, while Danny Welbeck and Wayne Rooney are expected to partner up front.
Tottenham v Wolverhampton Wanderers
Harry Redknapp's side could go joint top of the Premier League for at least 48 hours if they can beat Wolves at White Hart Lane.
After midweek victory over Everton, the starting eleven is likely to remain unchanged, with Michael Dawson impressing upon his return to action.
Chelsea v Sunderland
Chelsea face a Sunderland side resurgent under Martin O'Neill, having won three of their last four matches under the management of the Irishman.
Andre Villas-Boas is without Didier Drogba and Salomon Kalou, who are both on international duty, while Michael Essien is not quite ready to return.
Liverpool v Stoke
Elsewhere, Liverpool captain Steven Gerrard will be looking to once again inspire his side to victory and get their push for the top four back on track.
Aston Villa v Everton
Aston Villa welcome Everton, when loanee Robbie Keane will be sure to be competing for attention with new Toffees signing Darron Gibson.
West Bromich Albion v Norwich/Blackburn Rovers v Fulham
Also on Saturday, West Brom face Norwich at the Hawthorns, while bottom of the table Blackburn Rovers need a result against Fulham.
Swansea v Arsenal
On Sunday, Swansea welcome Arsenal to the Liberty Stadium with the away side aiming to bounce back from defeat at Fulham last time out.
Thierry Henry and looks set to start, with Arsene Wenger suggesting the Gunner legend could play out wide, flanking Robin van Persie.
Newcastle v QPR
Finally on Sunday, Mark Hughes needs to hit the ground running in his first game as QPR boss, with his side just 1 point clear of danger.
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