Toure has departed the Etihad Stadium to join up with Ivory Coast on Africa Cup of Nations (AFCON) duty and is not feeling great about being away.
Winning the AFCON is his current priority but he insists he will come back determined to push the Citizens over the line as champions.
“I do feel a bit guilty. I said to my wife it's difficult to be away from City right now,” he told The Sun.
“But if I win the Cup of Nations and then come back and win the league it will be the most amazing season for me. And I'm very positive we can do it.
“Very positive that the Ivory Coast can win the Cup of Nations. And City win the Premier League. It will be very hard, very, very difficult.
“But all my countrymen believe we can win the cup and all City fans believe we can win the League.”
The former Barcelona man is expected to be away until mid-February, as the Ivory Coast are one of the favourites to lift the trophy.
On the other hand, Manchester City face a tough fixture with third placed Tottenham Hotspur on Sunday.
It will be crucial to their title bid to win the game, especially since Manchester United face a realistic chance of dropping points when they travel to Emirates Stadium and a clash with Arsenal just a couple of hours.
It will be a tough task for the Citizens as they will be missing captain Vincent Kompany through suspension, as well as Yaya’s brother Kolo.
The younger of the two Toures, Yaya is seen as City’s biggest due to him becoming an integral part of their success since his £24million pound move from Barcelona.