Kompany has missed the past four games for the Etihad Stadium club through suspension, after being shown a straight red card against Manchester United.
“It is important that we have Vincent available,” Mancini is quoted as saying on Sky Sports.
“He is our leader and a very strong defender, one of the best in Europe. And because he is so young, he can improve.”
The City captain’s return will come as a boost to Mancini as his side’s usually tight defence has looked somewhat vulnerable in recent weeks, most notably in the Carling Cup semi-final loss to Liverpool.
Much of the defensive instability blame has been laid at the feet of new young centre-half Stefan Savic, who has been filling in alongside Joleon Lescott during Kompany’s absence.
Normally Kolo Toure would be expected to fill in any spaces in the centre of defence, but he is also unavailable due to being away on international duty with Ivory Coast at the Africa Cup of Nations.
City’s next game is an away fixture with Everton in the Barclays Premier League tonight.
The return of the Belgium international will increase the Citizens chances of success at Goodison Park – somewhere they have won just once in their last 13 visits.