Arsenal v Blackburn
Arsenal will be looking to get back to winning ways when they kick off this weekend's Premier League action against Blackburn on Saturday.
Having won just 1of their last 6 league games Arsenal will be boosted by Bacary Sagna's returm - although Alex Oxlade-Chamberlain is a doubt.
Manchester City v Fulham
City will be confident of moving past their own recent struggles, having won every single league game they have played at the Etihad this season.
Loan signing David Pizarro could make the match day squad, while Micah Richards is expected to return from injury. Mario Balotelli remains suspended.
Wigan v Everton
Bottom of the table Wigan are in desperate need of a result, with Roberto Martinez's side winning just 3 games in the league so far this season.
But they face an Everton side greatly reinforced by deadline day signings Nikica Jelavic and Steven Pienaar - who will both likely make their debuts.
Stoke v Sunderland
A Sunderland side revitalised under Martin O'Neill face perhaps their toughest test under his management - a trip to the Britannia to face Stoke.
Elsewhere, QPR will be hoping their new signings can secure a win against Wolves, while West Brom welcome Swansea and Norwich face Bolton.
Chelsea v Manchester United
Sunday afternoon sees a huge game between United and Chelsea, with the home side looking to secure 4th and the Red Devils joint top of the league.
Sir Alex Ferguson has received a big boost with the news Wayne Rooney, Nani and Phil Jones are all set to return from injury in time to face the Blues.
Chelsea meanwhile are without key players, with Ashley Cole suspended, Ramires injured and John Terry ruled out. Gary Cahill could make his debut.
Newcastle v Aston Villa
Finally on Sunday, high flying Newcastle United welcome Aston Villa to St James' Park, looking to continue their push for a top five finish.