The two most successful sides in the history of the English game go head-to-head for the 39th time in the Premier League era, and with United chasing a 20th league crown.
GMF takes a look back at some classic matches between the two sides at Old Trafford in more recent years...
Manchester United 2-2 Liverpool - October 1, 1995
Eric Cantona was supposed to take the headlines, but they ended up going to Liverpool striker Robbie Fowler as he netted twice to secure a point for the visitors.
Cantona returned to action for United after serving a lengthy suspension for his infamous kung-fu kick, and made an almost instant impact as he provided the assist for Nicky Butt to open the scoring after two minutes.
But bleached-blonde Fowler restored parity when he expertly fired past Peter Schmeichel after cutting in from the left-flank, before providing Liverpool with a deserved lead thanks to a delicate chip.
Cantona did, however, equalise from the spot after Jamie Redknapp felled Ryan Giggs, but the Frenchman had been upstaged by Fowler.
Manchester United 0-1 Liverpool - December 17, 2000
Liverpool secured their first win of the Premier League era at Old Trafford thanks to a wonderfully executed free-kick from Danny Murphy.
After the two great rivals had played out a relatively even opening 40 minutes, Gary Neville handled on the edge of the area to provide Murphy with the chance to test Fabien Barthez.
The Liverpool midfielder then proceeded to expertly whip the ball over the United wall; curling into the top-right corner of Barthez's net.
United were unable to draw level in the second-half, and Luke Chadwick saw red late on after following Liverpool substitute Vladimir Smicer.
Murphy went to score the deciding goal at Old Trafford in two out of the next three seasons.
Manchester United 4-0 Liverpool - April 5, 2003
The major talking point after this encounter was the performance of referee Mike Riley, who twice awarded Manchester United penalties.
The first of which came after only four minutes and saw Liverpool captain Sami Hyypia sent off for bringing down Ruud van Nistelrooy.
Van Nistelrooy converted from the spot to give his side the lead, and doubled the advantage an hour later when Igor Biscan conceded another penalty after fouling Paul Scholes.
Ryan Giggs netted his first league goal for two years to make the score 3-0, before Ole Gunnar Solskjaer completed the rout in stoppage time.
Manchester United 1-4 Liverpool - March 19, 2009
Liverpool gave their title ambitions a much needed boost in a convincing win at Old Trafford, some four days after beating Real Madrid 4-0 at Anfield.
Cristiano Ronaldo had opened the scoring for the home side after converting penalty conceded by Pepe Reina after 23 minutes.
Fernando Torres, though, outmanoeuvred Nemanja Vidic and showed great composure to finish past Edwin van der Sar only five minutes later.
Steven Gerrard then won a penalty after exchanging passes with Torres, and the Liverpool captain made no mistake from the spot.
As United pushed for an equaliser in the second-half, a Liverpool counter attack was ended when Vidic hauled down Gerrard and was sent off.
Fabio Aurelio scored from the resulting free-kick, before Andrea Dossena rubbed further salt into United wounds with a superb lob.
Manchester United 3-2 Liverpool - September 19, 2010
The last Premier League encounter between the two ended in quite sensational fashion as Dimitar Berbatov netted a late winner for the home side.
United had streaked into a two goal lead thanks to a brace from Berbatov, with each strike coming either side of the half-time interval.
The opener was a header from a Ryan Giggs corner after Berbatov had evaded Fernando Torres, and the second a spectacular overhead kick.
Liverpool, though, drew level with two goals in six minutes from Steven Gerrard, but this remarkable turnaround proved fruitless when Berbatov glanced home to complete his hat-trick.