The Togolese striker assisted all of Spurs' opening four goals at White Hart Lane, before finding the net himself with a well-taken goal his performance deserved after setting the tone for Harry Redknapp's side.
The win keeps the club's faint title hopes alive, after they recorded another positive result which has seen them lose just two of their last 23 games in the Premier League.
"We played some great stuff and Adebayor set the tone in that first 20 minutes, he was amazing," Redknapp told the club's official website. "He was absolutely on fire and the movement up front was fantastic with Saha.
"They were a real threat and Newcastle couldn't handle them. Every time we played the ball forward we caused them problems."
The game also produced two goals for January deadline day signing Louis Saha, who, making his home debut for his new club, looks to have immediately won the hearts of the Tottenham Hotspur faithful.
The result means Spurs are now 10 points clear of nearest rivals Arsenal and Chelsea, and sit comfortably positioned in third place.
"The goals came early and that put us in a great position," added Redknapp. "The game would have done Ade the world of good. He was fantastic."
Tottenham return to FA Cup action against Stevenage Borough next weekend before the enforced international break, then after fans will be licking their lips at the prospect of another north London derby, as an away trip to Arsenal awaits.