Liverpool v Arsenal
The weekend's action kicks off at Anfield, with Liverpool on a high after last weekend - when the Reds were crowned Carling Cup champions.
Arsenal will also be feeling confident after thrashing rivals Tottenham last Sunday, in a comeback that has inspired hopes of a top 4 finish.
But the Gunners have been dealt a huge blow after Arsene Wenger revealed captain Robin van Persie is doubtful for Saturday's game.
West Bromich Albion v Chelsea
Chelsea are away to West Brom hoping to maintain momentum in the league as Andre Villas-Boas under pressure to achieve a top 4 finish.
Didier Drogba is a doubt for the Blues, with Fernando Torres almost certain to take his place and return to the starting line up in attack.
Manchester City v Bolton
League leaders City meanwhile will be firm favourites against Bolton, with Roberto Mancini's squad fully fit for the first time since November.
QPR v Everton; Stoke City v Norwich City
With just two wins in eight games, Mark Hughes is desperate for a 3 points, while the Potters can move above Norwich if they can beat that at home.
Wigan v Swansea; Blackburn v Aston Villa
Roberto Martinez's side can climb out of the relegation zone with a win, while defeat for Villa could would be disastrous for under fire Alex McLeish.
Tottenham v Manchester United
Sunday sees a huge clash between Tottenham and Manchester United, with the Red Devils aiming to keep pace with leaders City with a win at the Lane.
Harry Redknapp has been dealt a double blow ahead of the game, with Gareth Bale a doubt - and Wayne Rooney ruled fit to start for Sir Alex Ferguson's side.
Newcastle v Sunderland; Fulham v Wolves
Finally, Newcastle are looking to keep their dreams of European football alive with a win against Sunderland in a huge Tyne-Wear derby, while Wolves travel to in form Fulham.