Paul Scholes is likely to return to the Manchester United starting eleven after he was an unused substitute against Athletic Bilbao.
Sir Alex Ferguson will assess the fitness of Phil Jones before deciding on his inclusion, as the England international missed Thursday's Europa League defeat through illness.
Wolves manager Terry Connor has no new injury concerns going into the fixture. Karl Henry remains sidelined for the Midlands club due to a hamstring injury but the midfielder could return in time for the crucial trip to Norwich next weekend.
The visit of the reigning Champions will pose a stern test for Conner's side, who have lost the last six home games. Their form at Molineux has been dire, with no win in eight and United are exactly the side Wolves could have done without facing as they boast the best away record in the Premier League.
There is extra incentive for Ferguson's side as victory will send them four points clear at the top of the table. City don't get the chance to respond until they face Chelsea at home on Wednesday.
Manchester United goalkeeper David De Gea has turned in a string of fine performances and the Spaniard believes concentration will be key if United are to win another Premier League trophy.
"It's very important for us now to try and secure the Premier League," said De Gea. "We have a big game coming up at Wolves on Sunday and that is what we must concentrate on now."
Wolves sit second-bottom and without a win since their 2-1 victory at QPR. Heavy defeats to West Brom and Fulham have not helped their relegation fight and Wayne Hennessey believes the experience of last year's escape will help them this season.
"We have been in difficult positions over the last couple of seasons and we got out of them which is a good sign," said Hennessey. "There are still a lot of us who have come through both seasons and we can use that experience."
The Wolves goalkeeper indicated that his side's home form has been a problem and needs to turn around if they are to have any chance of survival. "We have to make it so that Molineux is a tough place to come. United may be top of the league and playing well but it's up to us to make it difficult for them and maybe we can play at the top of our game and get a bit of luck as well."