Tottenham v Bolton
Tottenham take on Bolton in the FA Cup on Saturday, desperate to bounce back from a run of three straight defeats in the Premier League.
The 8 time winners could welcome Aaron Lennon back to the side, while Jermain Defoe is expected to start having impressed recently.
Everton v Sunderland
Everton meanwhile welcome Sunderland to Goodison, with David Moyes side in form - having beaten City, Chelsea and Spurs since January.
Chelsea v Leicester
Chelsea, on a high after their stunning midweek Champions League comeback, face Leicester on Sunday having won their last 3 games.
David Luiz is hoping to shake off a knock to make the team, while Didier Drogba is set to continue in attack ahead of Fernando Torres.
Liverpool v Stoke
Elsewhere, Liverpool face Stoke - looking to reach the semis and visit Wembley for the second time this year - following their Carling Cup triumph.
Fulham v Swansea & Wigan v West Brom
In the Premier League, Fulham welcome Swansea with both sides level in the table, while rock bottom Wigan face West Bromich Albion.
Wolves v Man Utd
On Sunday, Manchester United will be looking to bounce back from their disappointing midweek Europa League exit at the Molineux.
Paul Scholes and Phil Jones are in line to return for the Red Devils as they look for a win that would take them four points clear at the top.
Newcastle v Norwich
Finally, Newcastle and Norwich bring the weekend's football to a close, with Alan Pardew's side still holding out hope of European qualification.