Of the Premier League's bottom five clubs, only Wigan and Wolves are in action this weekend, which affords them the opportunity to strike a significant blow to their relegation rivals.
Basement club Wigan could climb out of the relegation zone with three points against West Brom on Saturday, as Roy Hodgson's side travel to the DW Stadium.
A win for the Latics would see Wolves drop to the bottom of the table, and their task will not get any easier when they face league leaders Manchester United at Molineux on Sunday afternoon.
Things have gone from bad to worse for Wolves since the sacking of Mick McCarthy, and interim boss Terry Connor has seen his team fall to consecutive defeats without scoring a goal.
An unlikely win, however, would see Wolves climb two places and drag Blackburn closer to the drop zone after last weekend's victory for Steve Kean's side.
Queens Park Rangers also remain in serious danger and, with the Hoops not scheduled to play until Wednesday, they could be bottom when they take on Liverpool at Loftus Road.