Chelsea captain John Terry will miss Wednesday's trip to Manchester City with a calf strain.
The former England skipper was substituted during extra-time of the Blues' dramatic Champions League victory over Napoli last week, after a remarkable return from knee surgery.
But the crunch visit to the Etihad Stadium this week comes too soon for the 31-year-old.
"It's still a bit early for John," interim manager Roberto Di Matteo said. "He did very well to come back in such a short period of time and we were lucky he came back so early.
"John is a crucial member of our team and a leader on the pitch so it's better when he is available but I expect him to be okay for game with Tottenham at the weekend.
"I have to manage everybody, not just one player. The run of games we face will be very demanding on the team so I have to manage that."
The loss comes as a big blow to Chelsea's top four ambitions, while Terry is now a doubt for next week's Champions League quarter final first-leg against Benfica.
David Luiz is likely to partner Gary Cahill in the centre of the Blues defence on Wednesday, with the Brazilian now in line to face his former side Benfica next week for the first time since moving to Stamford Bridge.
Di Matteo faces a further selection dilemma in attack in the coming week, with Fernando Torres' showing against Leicester City putting him in contention.