The 21-year-old Bologna playmaker has attracted interest from a host of top European clubs, and is expected to leave Serie A this summer.
Sky Sports reports how Ramirez signed a new long-term contract to remain in Italy back in November, but the Uruguayan could now make a shock exit after a series of eye-catching performances for the Rossoblu this season.
Red Devils boss Sir Alex Ferguson is believed to be monitoring the South American star's situation, as he weighs up a bid to bring him to Old Trafford.
However, Manchester United could face competition from Premier League rivals Liverpool, who are also keen to lure him to Anfield, and join a growing contingent of Uruguayan players, following in the footsteps of compatriots Luis Suarez and Sebastian Coates.
"I can tell you with certainty that there are negotiations ongoing in Buenos Aires with a major English side which is ready to buy both the 70 per cent owned by Bologna and the 30% of Penarol," Betancourt told calciomercato.com.
"There are other clubs interested, like Juventus, but the only concrete offer comes from England and I will soon bring it to Bologna.
"Will Ramirez leave next summer? Given the amount of clubs interested, I would say yes."