Aston Villa v Chelsea
In the Premier League this weekend, Roberto Di Matteo's side travel to Villa Park needing a result as they chase Champions League qualification.
Didier Drogba and Frank Lampard are expected to start having been rested in midweek, while Branislav Ivanovic returns from injury.
Manchester City v Sunderland
Manchester City can go level with rivals Manchester United if they can maintain their 100% home record when Sunderland visit on Saturday.
Roberto Mancini is without club top scorer Sergio Aguero, but Carlos Tevez and Vincent Kompany are set to return to the starting line up.
QPR v Arsenal
Arsene Wenger has urged his side to keep their focus ahead of their trip to QPR, with the Gunners chasing an eight consecutive league win.
Laurent Koscielny has been ruled out for Arsenal, while QPR are without Djibril Cisse, who serves the first of a four match suspension.
Everton v West Brom
Everton will be hoping to maintain their good form against the Baggies, with confidence high after midweek FA Cup quarter-finals success.
Wolves v Bolton
A relegation six pointer sees Wolves facing a must win game - but Terry O Connor's side have only won once in their last 16 league games.
Fulham v Norwich, Wigan v Stoke
Elsewhere this weekend, Fulham face Norwich while Wigan will be keen to maintain momentum after last week's shock win at Liverpool.
Newcastle v Liverpool
On Sunday, Andy Carroll faces former club Newcastle at St James's Park for the first time since his £35m to Anfield in January of last year.
Liverpool have lost 5 of the their last 6 games, but face a tough task against a high-flying Newcastle side challenging for European football.
Charlie Adam and Craig Bellamy have been ruled out for the Reds, while Fabricio Coloccini and Chieck Tiote are doubts for the home side.
Tottenham v Swansea
Tottenham and Swansea bring the weekend's action to a close at White Hart Lane with the home side continuing their pursuit of 3rd place.
Aaron Lennon could return as Spurs look to put a disappointing run behind them - having gained 2 points from a possible 15 in their last 4 games.