Sunderland v Tottenham
Tottenham kick off this weekend's Premier League action at Sunderland, continuing their push for Champions League qualification this season.
The Black Cats will be wary of the in form Rafael van deer Vaart, as well as Aaron Lennon - whose return have given Spurs a much needed boost.
Chelsea v Wigan
Chelsea need a win on Saturday, with Roberto Di Matteo's side five points behind top four rivals Spurs and level with high flying Newcastle.
Fernando Torres is finding form at the right time, but the Blues may well be without captain John Terry, who picked up a knock in midweek action.
Liverpool v Aston Villa
Under pressure manager Kenny Dalglish will be desperate for a result when Villa visit Anfield having lost five of their last six league matches.
Brazilian goalkeeper Alex Doni will step in for the suspended Pepe Reina as the Reds look to end their worst league run for 59 years.
Bolton v Fulham; West Brom v Blackburn
Also on Saturday, Bolton welcome Fulham, while Roy Hodgson's West Brom welcome a Blackburn side who are still fighting for their survival.
Norwich v Everton; Stoke City v Wolves
Elsewhere, Everton could move further above Mersey side rivals Liverpool with a win at Norwich, while bottom of the table Wolves face Stoke City.
Manchester United v QPR
On Sunday, Manchester United can go 8 points clear at the top of the Premier League if they can beat relegation threatened Queens Park Rangers.
Mark Hughes side have secured impressive wins against Arsenal and Liverpool recently, but Sir Alex Ferguson's side will be firm favourites.
Arsenal v Manchester City
The weekend's big game sees Arsenal welcome City in a clash that could have huge consequences in the race for the top four as well as the title race.
Sergio Aguero and Jolean Lescott returns for City, while Arsenal, who are level on points with rivals Spurs, have a near fully fit squad available.