Manchester United v Everton
Manchester United can go eight points clear of Manchester City with a win over Everton - at least until their local rivals play Wolves later on Sunday.
Sir Alex Ferguson's men will face a tough challenge against the Toffees though, with the David Moyes' side unbeaten in their last four league matches.
Wayne Rooney will be looking to maintain his impressive strike rate this weekend, with the former Evertonian's tally standing at 31 goals this season.
Liverpool v West Brom
Liverpool meanwhile welcome West Brom, with Kenny Dalglish's side hoping to put a miserable run of form firmly behind him with a win over West Brom.
The Reds beat Everton in the FA Cup semi-final last week, having won at Blackburn the Monday before - with Andy Carroll scoring the winner in both games.
Wolves v Manchester City
City can keep up the pressure on league leaders United with a win at Molineux - and all but confirm Wolves relegation from the Premier League.
Sergio Aguero and Carlos Tevez will continue their deadly partnership up-front, with the Argentine pair scoring eight goals between them in City's last two games.