The Catalan side lost in the semi-final first-leg 1-0, having dominated the game – enjoying 70 per cent possession and a total of 25 shots to Chelsea's four.
"We'll have our chance to go through if we play like we did at Stamford Bridge. We need to control the match and I'm sure that we'll have our chance," said the Spaniard.
The Nou Camp – which is two yards longer and one yard wider than the Stamford Bridge pitch - is the setting for the conclusion of the tie.
With suggestions that Chelsea will suffer from the size of the pitch - especially during the latter stages of the game - Pique does not believe the Blues will succumb to fatigue, insisting they are a 'strong and experienced team.'
"When you talk about a Champions League semi-final, fatigue doesn't influence the team. Being tired is an excuse for losers," added the defender.
Pep Guardiola's side lost 2-1 against Real Madrid at the Nou Camp to effectively end their title challenge, which was followed by talk of an 'end of an era'.
While Pique believes Barcelona deserve more recognition, he went on to congratulate Jose Mourinho's side for their win in El Clasico.
"Talk of an end of an era comes easy here. A team that has won 13 out of 16 titles deserves a bit more credit. We have to wait for another team to win as much as we have until all this talk is confirmed.
"They've [Madrid] had a fantastic season, especially in the Liga. I want to congratulate them and say that we'll be here next year," he continued.
The Blaugrana defender was dropped for the matches against Chelsea and Madrid, but has stated that whether he plays or not, winning is the most important thing.
"I have to accept the decision with professionalism. The important thing is winning, not if I play."