The Belgian admits that Tony Pulis' side will be a tough opponent, but he has called on his teammates to rise to the challenge, score goals and claim all three points.
"It is always a hard game when we go there, you know it is going to be a battle," Vermaelen told Arsenal Player. "If there is a battle, sometimes you have to fight back.
"But the main thing is to play our own game, with quick passing. That is the way to score. Of course we must fight for every ball but the main thing is to keep to our own game and score a lot of goals."
Arsene Wenger's men have lost three of their last four games at the Britannia in all competitions, however, a win for the Gunners will see them tighten their grip on third - the last automatic Champions League qualification spot.
A win for Stoke – who are unbeaten in their last four home games, including a draw against Manchester city - will put them in good stead to end the season in the top half of the table, as they currently sit in 14th, three points behind West Brom in 10th, but with a game in hand.
Vermaelen believes that Arsenal are better prepared for the aerial threat that the Potters posses, having focused on defending set pieces.
"We always want to defend well as a team, we have to do that on Saturday," he added. "It won't be easy, and we have to be focused on set pieces."