With Newcastle just three points behind and with a game in hand, Arsenal will want strengthen their grip on third with a win at Stoke on Saturday.
With Mikel Arteta and Theo Walcott out for the remanding three games of the season, manager Arsene Wenger is facing a shortage in midfield.
After a disappointing league campaign, Liverpool will be desperate to at least finish above Merseyside rivals Everton, who are two points ahead.
A result at Norwich would lift them above David Moyes' side, but the Reds have only managed to win three of their last 16 Premier League fixtures.
Newcastle can continue their fantastic run of form if they can secure an incredible seventh consecutive Premier League victory at Wigan.
Three points would boost the Magpies challenge for Champions League football next season, maintaining their lead over rivals Spurs.
Villa meanwhile need a win if they are to avoid a relegation battle, with Alex McLeish under fire and his side just three points above the drop zone.
Bolton face a Sunderland side without a win in five games as they look to take advantage of their game in hand and climb out of the bottom three.
Elsewhere on Saturday afternoon, Everton welcome Fulham, while Wolves travel to Swansea with Terry Connor's side already relegated.