Gareth Bale has pulled out of Wales' friendly against Mexico in New York next Sunday, with five other first-choice squad members also withdrawing.
All six are listed as "injury concerns" by the Football Association of Wales, who also confirmed Celtic's Joe Ledley, Blackpool's Neal Eardley, Cardiff's Darcy Blake, Sunderland's David Vaughan and Crystal Palace's Lewis Price would not make the trip to the United States.
Wales manager Chris Coleman has called up five players to replace the absentees.
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