Frank Lampard has been ruled out of the European Championships after sustaining a thigh injury, and Jordan Henderson will be added to England's squad to replace him.
The Chelsea midfielder underwent a scan on Thursday to assess the extent of the damage, and it has been deemed he will not be fit enough to compete at the tournament in Poland and Ukraine.
Henderson was placed on standby after Lampard was injured on Wednesday, and the Liverpool youngster will join up with the squad subject to agreement from UEFA’s medical team.
England manager Roy Hodgson has already had to contest with the withdrawal of Gareth Barry from his initial 23-man squad, and opted to bring in another defender - Phil Jagielka - rather than a midfielder to replace the Manchester City man.
“It’s a huge blow for the team, especially coming after the loss of another senior player in Gareth Barry," said Hodgson in a statement.
"The fact that the doctor cannot guarantee Frank could take part in any of the group matches means we have to replace him in the central midfield area.
“Apart from it being a huge blow to me and the team, I’m especially disappointed for Frank himself.
"He has been in very good form and was looking forward to the tournament. He made a huge contribution towards us qualifying for the Euros so it is cruel to be forced out through injury just before the tournament.”
In a press conference on Wednesday, Lampard claimed he had no plans to retire from international football, and the 33-year-old did not expect Euro 2012 to be his last tournament with England.