Sergio Aguero, Gareth Barry and Micah Richards will all miss the visit of QPR today.
Four months ago this fixture decided the fate of the Premier League title, but that day’s hero, Sergio Aguero, misses the fixture through a knee injury suffered on the opening day of the season.
New City signings Javi Garcia, Scott Sinclair, Matiji Nastasic and Maicon will all get a first look at their new club, and Roberto Mancini could recall Joleon Lescott and Jack Rodwell to the team after both were dropped for the trip to Liverpool.
Carlos Tevez is expected to continue in attack, and David Silva will almost certainly return to the side after warming the bench at Anfield.
Both of last season’s fixtures between the sides finished 3-2, and Mancini will be eyeing three points again on his 100th match in charge of City.
Mark Hughes could hand a debut to Esteban Granero. The £10m capture from Real Madrid was one of the coups of the transfer window, and the classy Spaniard is expected to play a big part in QPR’s season.
But Brazil international Julio Cesar will not play at the Etihad Stadium – the former-Inter Milan shotstopper is still awaiting international clearance.
Both sides were extremely busy as the transfer window closed yesterday, but Manchester City, unsurprisingly, spent the most money.
The capture of Javi Garcia from Benfica was the day’s most expensive signing, a fee believed to be £16m was agreed between the two clubs, while Fiorentina defender Nastasic joined for around £11m.
The 19-year-old centre-back is highly rated, and offers competition for Lescott and Vincent Kompany in the City defence.