John Terry is fit to face Queens Park Rangers after recovering from the ankle injury he sustained during England's 5-0 win in Moldova.
The Chelsea defender is likely to be the main focus of attention prior to kick-off following his high profile court case with QPR defender Anton Ferdinand, as the Premier League confirmed the pre-match handshakes would go ahead as planned.
Fellow England defender Ashley Cole should also be fit, and is in contention to start after missing the World Cup qualifiers with an ankle problem. Juan Mata is back in the team and Marko Marin will play for the under-21's as he continues his comeback from a hamstring complaint.
For QPR, Ferdinand is set to be included after recovering from a shoulder problem.
For Chelsea, Fernando Torres is set to make his 50th Premier League appearance.
It was in this fixture last season that the Terry-Ferdinand affair flared up, and led to a lengthy court case that eventually exonerated the Chelsea captain. QPR won that match 1-0 in what proved to be the beginning of the end for then-Chelsea boss Andre Villas-Boas.
But the Blues do not have a good record at Loftus Road, having won just two of 17 top flight games at the stadium.
Form suggests it should be a cagey affair, as four of the five previous meetings between the two clubs in all competitions have ended 1-0, and Chelsea boss Roberto Di Matteo is anticipating a close match.
"Every time we go to Loftus Road it is always a feisty derby for us," said Di Matteo. "It is a small ground with very passionate supporters from both sides, and the rivalries are well known so it is going to be a heated atmosphere."