Liverpool welcome Manchester United to Anfield in the day's early kick off as Brendan Rodgers recalls his key players.
Steven Gerrard, Luis Suarez and Daniel Agger were all rested in mid-week but should return to the Liverpool team, while Manchester United will have to do without injured duo Wayne Rooney and Ashley Young.
The day's four o'clock fixtures sees Arsene Wenger bring his Arsenal team to the Etihad Stadium, but injury to Wojciech Szczesny means Vito Mannone will once again deputise.
For Roberto Mancini, former-Gunner Samir Nasri looks set to miss the visit of his former club with a hamstring complaint, but Mario Balotelli and Sergio Aguero should be available.
Sunday's other games see Newcastle host Norwich at the Sports Direct Arena in the three o'clock kick off while Tottenham face QPR at White Hart Lane.