Robin van Persie's late penalty gave Manchester United a 2-1 victory over Liverpool on a poignant Sunday afternoon at Anfield.
On an occasion where the Hillsborough victims and families were remembered, these two great Premier League rivals produced a typically competitive encounter.
Brendan Rodgers' side were reduced to 10 men when Jonjo Shelvey was sent off for a first-half foul on United defender Jonny Evans. But, that didn't stop Reds captain Steven Gerrard volleying the home side into the lead moments after the restart.
United responded with a spectacular equaliser from Rafael Da Silva before Van Persie secured all three points after Glen Johnson fouled Antonio Valencia.
At the Etihad Stadium, Laurent Koscielny scored a late equaliser to earn Arsenal a 1-1 draw against Manchester City. The Frenchman cancelled out Joleon Lescott's first-half header when he thumped in from close range, after the champions failed to clear a corner.
The goal maintains both clubs' unbeaten starts to the season, leaving the Gunners and City locked together on eight points from five matches.
Tottenham scored twice in as many minutes as they fought back to beat Queens Park Rangers 2-1 at White Hart Lane, handing Andre Villas-Boas his first home win of the season.
Bobby Zamora gave the visitors the lead against his former club, but an Alejandro Faurlin own goal restored parity, before Jermain Defoe struck the winner with his fourth goal of the season.
A late goal from Ashley Cole helped Chelsea down Stoke City 1-0 at Stamford Bridge to help Roberto Di Matteo's side move three points clear at the top of the table.
Meanwhile, Everton won 3-0 against Swansea at the Liberty Stadium with goals from Victor Anichebe, Kevin Mirallas and Marouane Fellaini. The hosts conceded twice before half-time but were reduced to 10 men when substitute Nathan Dyer was sent off 12 minutes after coming on.
Southampton secured their first points of the season with an emphatic 4-1 victory over Aston Villa. Rickie Lambert netted twice, with further goals from Nathaniel Clyne and Jason Puncheon. Darren Bent scored for the visitors on a forgettable day at St Mary's.
Hugo Rodallega returned to haunt his old club when he helped fire Fulham to a 2-1 victory over Wigan at the DW Stadium. Damien Duff doubled the lead while Arouna Kone pulled one goal back, but it wasn't enough for the Latics.
West Brom beat Reading 1-0 at The Hawthorns with the goal coming courtesy of a goal from on-loan Chelsea striker Romelu Lukaku.
And finally, Demba Ba scored his third goal in two games to secure a 1-0 win for Newcastle and spoil Norwich manager Chris Hughton's return to St James' Park.
Papiss Cisse missed a penalty, but it didn't matter as the Magpies eased past the Canaries, who are still yet to win in the league this season.