Tottenham Hotspur manager Andre Villas-Boas showed he’s taking this competition very seriously with the team that lined-up against Lazio, and the former Porto boss is expected to again name a strong team for the trip to Greece.
French international stopper Hugo Lloris is expected to retain his place in the competition after failing to dislodge Brad Friedel in the Premier League, whilst Steven Caulker and Jan Vertonghen are expected to play at the heart of defence after impressing at White Hart Lane recently.
Sandro and Moussa Dembele can expect to play the holding role in midfield, as Villas-Boas likes to play two defensive-midfielders when away from home with Spurs.
Clint Dempsey can expect to start after his weekend goal at Old Trafford, whilst Gareth Bale could get the nod ahead of Icelandic international Gylfi Sigurdsson.
Aaron Lennon is again expected to start on the right for Spurs ahead of Andros Townsend, whilst Jermain Defoe is the only fit striker on the books as Emmanuel Adebayor recovers from injury.
Tottenham Hotspur predicted line-up v Panathanaikos:
Hugo Lloris; Kyle Walker, Michael Dawson, Steven Caulker, Jan Vertonghen; Sandro, Moussa Dembele; Aaron Lennon, Clint Dempsey, Gareth Bale; Jermain Defoe.