Defeat to Manchester United almost two weeks ago was a bitter pill to swallow for the Liverpool faithful, but the club's owners have become reluctantly accustomed to losing out against their biggest rivals.
Fenway Sports Group's other team across the Atlantic, the Boston Red Sox, have just ended their worst season for 47 years - which included a staggering 13 losses against arch rivals the New York Yankees.
Liverpool fans would loath to contemplate losing just once to Manchester United in a single season, but can surely be thankful they do not have to face a pummelling similar to their American brothers.
John Henry, owner of Liverpool and the Red Sox, can hardly buy any luck at the moment - and he has certainly tried - with both his sides breaking records they would rather forget.
Liverpool recorded their first league win of the Premier League season last Saturday with a 5-2 defeat of Norwich after beginning the campaign in the worst fashion for over a century.
Meanwhile, the Red Sox's most disappointing season for almost 50 years included a run of 26 defeats in their final 33 contests, and 93 losses over the campaign as a whole.
And, as if to rub it in even further, their final outing ended in a humiliating 14-2 loss to - you guessed it - the Yankess, who progressed into the playoffs.